10Best.Guide

Methylfolate

Top Picks

Last Updated: May, 2023
Pros
  • Effective for people with MTHFR gene mutation
  • More cost-effective than prescription Deplin
  • Helps with memory-retrieval issues, leg cramps, PMS, and homocysteine levels
  • Provides more energy, less compulsive behavior, less depression, and more focus and concentration
Cons
  • May not work for everyone
  • Contains soy, which may be a problem for some people
Bottom Line
This product is an effective and cost-effective option for people with MTHFR gene mutation or other related issues. However, it may not work for everyone and contains soy, which may be a problem for some people. It is also more expensive on Amazon compared to other websites and is not FDA-approved.
Pros
  • Helps with low mood, low energy, and focus issues.
  • Significant difference for those with MTHFR mutation.
  • Boosts mood in conjunction with antidepressants.
  • Thorne brand is effective for MTHF gene mutation.
  • Miracle pill for anxiety, depression, and focus issues.
Cons
  • Severe migraine and other side effects for those with MTHFR gene mutation.
  • Worst headaches and nausea for some users.
Bottom Line
This supplement is effective for those with MTHFR gene mutation and can help with low mood, low energy, and focus issues. However, it may cause severe side effects for some users and may not be effective for everyone. It is important to consult with a healthcare provider before taking this supplement.
Pros
  • Effective for those with MTHFR mutation
  • Helps with mental health and energy levels
  • Good results for those with low folate levels
  • Comparable to prescription strength methylfolate
  • Recommended by healthcare professionals
Cons
  • Expensive compared to other supplements
  • May cause high methylfolate levels in some individuals
Bottom Line
MethylPro is an effective supplement for those with MTHFR mutation, low folate levels, and mental health issues. However, it is more expensive than other supplements and may cause high methylfolate levels in some individuals. It is recommended by healthcare professionals and comparable to prescription strength methylfolate.
Pros
  • Bioavailable form of folate
  • Natural form of folate
  • Helps with anxiety
  • Helps with MTHFR gene mutation
  • Helps with symptoms of MTHFR
Cons
  • No noticeable difference in anxiety
  • No appearance or size information on the label
Bottom Line
Jarrow Formulas Methyl Folate is a bioavailable and natural form of folate that may help with anxiety, MTHFR gene mutation, symptoms of MTHFR, IBS-D, and hair growth. However, it may cause sensitivity when taken with methyl b12 and adverse effects in some individuals.
Pros
  • Helps with depression and mood
  • Good for those with MTHFR gene mutation
  • Easy to swallow capsules
  • Reasonably priced compared to other brands
  • Helps with Chronic Fatigue Syndrome (CFS)
Cons
  • Inconsistent amount of capsules in each bottle
  • May not work for everyone
Bottom Line
L-methylfolate is a good supplement for those with MTHFR gene mutation, depression, and CFS. However, it may not work for everyone and may worsen migraines. It is reasonably priced and easy to swallow, but some bottles may have inconsistent amounts of capsules. It is not as effective as prescription Deplin.

The Ultimate Buying Guide for Methylfolate: Types, Key Considerations, Features, Prices, Tips, and FAQs

Overview

Methylfolate is a form of folate that plays a crucial role in methylation, a process that regulates gene expression, detoxification, and neurotransmitter synthesis. Methylfolate supplements are popular among people with genetic mutations, such as MTHFR, that impair folate absorption. In this buying guide, we'll explore the different types of methylfolate supplements, key considerations when choosing a supplement, features to look for, prices, tips, and FAQs.

Types

- L-methylfolate calcium: This is the most common form of methylfolate used in supplements. It's highly bioavailable and well-tolerated.

- Quatrefolic: This patented form of methylfolate is claimed to have superior stability and solubility compared to other forms.

- Metafolin: This is a brand of L-methylfolate that's used in some supplements. It's made by Merck KGaA and has been clinically tested for safety and efficacy.

Key Considerations

- Absorption: Look for supplements with highly bioavailable forms of methylfolate, such as L-methylfolate calcium.

- Dosage: Consult with a healthcare professional to determine the appropriate dosage for your needs.

- Supplements: Methylfolate is often combined with other B vitamins, such as B12 and B6, in multivitamin supplements.

- Health benefits: Methylfolate has been linked to improved mood, cognitive function, and cardiovascular health.

- Side effects: Some people may experience gastrointestinal discomfort or allergic reactions when taking methylfolate.

Features

- Quality: Look for supplements made by reputable brands that use high-quality ingredients and follow good manufacturing practices.

- Form: Methylfolate supplements come in different forms, such as capsules, tablets, and gummies.

- Price: Compare prices from different brands to find a supplement that fits your budget.

- Reviews and ratings: Check online reviews and ratings from other users to get an idea of the supplement's effectiveness and tolerability.

Prices

- Methylfolate supplements can range from $10 to $50 per bottle, depending on the brand, dosage, and form.

Tips

- Consult with a healthcare professional before taking methylfolate supplements, especially if you're pregnant, breastfeeding, or taking medication.

- Take methylfolate supplements with food to enhance absorption and reduce the risk of gastrointestinal side effects.

- Store methylfolate supplements in a cool, dry place away from sunlight and moisture.

FAQs

Q: What is methylfolate used for?

A: Methylfolate is used to support methylation, a process that regulates gene expression, detoxification, and neurotransmitter synthesis. It's also used to address folate deficiency and genetic mutations that impair folate absorption.

Q: What are the benefits of methylfolate?

A: Methylfolate has been linked to improved mood, cognitive function, and cardiovascular health.

Q: Are there any side effects of methylfolate?

A: Some people may experience gastrointestinal discomfort or allergic reactions when taking methylfolate.

Q: Can I get methylfolate from food?

A: Yes, methylfolate is found in foods such as leafy greens, legumes, and fortified cereals. However, some people may have difficulty absorbing folate from food due to genetic mutations or other factors.

Q: How do I choose the right methylfolate supplement?

A: Consider factors such as absorption, dosage, supplements, health benefits, side effects, quality, form, price, and reviews when choosing a methylfolate supplement. Consult with a healthcare professional to determine the appropriate dosage for your needs.

Runner-Ups

Pros
  • Helps with insomnia and promotes restful sleep.
  • Helps with hair loss.
  • Good for people with MTHFR gene mutation.
  • Helps with depression and anxiety.
  • Easy to swallow and no taste.
Cons
  • Can cause side effects like headaches and heart palpitations.
  • May not work for everyone.
Bottom Line
This product is a good option for people with MTHFR gene mutation, hair loss, and sleep problems. It may also help with depression and anxiety. However, it may cause side effects in some people and may not work for everyone. It is important to talk to a doctor before taking this supplement.
Pros
  • Helps with depression and Hashimoto's Disease
  • Reduces hair loss and increases energy levels
  • Good brand and recommended by doctors
  • Useful for MTHFR gene mutation and folate deficiency
Cons
  • Can cause restlessness, insomnia, and headaches
  • Adverse reactions can happen, be careful
Bottom Line
This product can be helpful for those with folate deficiency and MTHFR gene mutation, but it is important to be cautious of potential side effects and consult with a doctor before taking it regularly. It may not work for everyone and should not be taken as an everyday supplement.
Pros
  • Cheaper than other brands
  • Effective for depression and anxiety
  • High dose for the price
  • Recommended by psychiatrists
  • Helps prevent long term brain damage
Cons
  • Safety seal may not be effective
  • Can amplify effects of other medications
Bottom Line
This product is effective for depression and anxiety, recommended by psychiatrists, and is cheaper than other brands. However, it may not be covered by insurance, can amplify the effects of other medications, and may trigger mania in bipolar disorder.
Pros
  • High potency and fresh
  • Boosts energy and motivation
  • Helps with low folate levels
  • Stabilizes mood and energy
  • Affordable price and good quantity
Cons
  • Inconsistent packaging
  • Low dosage for people with low folate levels
Bottom Line
This product is a good option for those looking for an affordable and effective supplement to boost energy, stabilize mood, and maintain healthy folate levels. However, buyers should be aware of the low dosage and inconsistent packaging.
Pros
  • Improved cognitive function, motivation, and focus.
  • Increased energy and motivation.
  • Effective for incapacitating anxiety, social anxiety, and agoraphobia.
  • Good balance of B vitamins.
  • Effective for MTHFR gene mutation.
Cons
  • High doses may cause neon yellow urine.
  • No noticeable changes for some users.
Bottom Line
This product is effective for improving cognitive function, motivation, and focus, increasing energy and motivation, and treating incapacitating anxiety, social anxiety, and agoraphobia. It is also good for those with MTHFR gene mutation and provides a good balance of B vitamins. However, it may cause neon yellow urine and may not work for some users.
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